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. 1992 Mar;58(3):1043-5.
doi: 10.1128/aem.58.3.1043-1045.1992.

Inhibition of polyketide synthesis in Alternaria alternata by the fatty acid synthesis inhibitor cerulenin

M Hiltunen  1 , K Söderhäll
Affiliations

Inhibition of polyketide synthesis in Alternaria alternata by the fatty acid synthesis inhibitor cerulenin

M Hiltunen et al. Appl Environ Microbiol. 1992 Mar.

Abstract

The fatty acid synthase inhibitor cerulenin (50 to 100 micrograms/ml) inhibited production of the polyketide mycotoxins alternariol (AOH) and alternariol monomethyl ether (AME) by the mold Alternaria alternata. The results suggested that AOH synthesis was inhibited by a direct mechanism by cerulenin, whereas production of AME was probably limited by a shortage of the precursor AOH.

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