Primary lymphoma of the cervix uteri: a diagnostic challenge. Report of two cases and review of the literature
- PMID: 15754997
Primary lymphoma of the cervix uteri: a diagnostic challenge. Report of two cases and review of the literature
Abstract
Background: Primary non Hodgkin's lymphoma (NHL) of the cervix and vagina is uncommon; the incidence of uterine lymphoma is estimated to be less than 0.5% of all NHL. Patients regularly present with vaginal bleeding. The diagnosis is made on biopsy but this can be difficult on small samples which may not be representative of the lesion. Immunohistochemical analysis and often molecular techniques are required to confirm the diagnosis.
Cases: We report two cases of primary diffuse large B-cell lymphoma of the cervix. In the first case, the diagnosis could only be made on repeat biopsies. The second case presented as a cervical polyp.
Conclusion: Gynecologists should be aware of this rare clinical entity in order to apply the proper treatment.
Similar articles
-
Primary non-Hodgkin's lymphoma presenting as a uterine cervical mass.Singapore Med J. 2008 Mar;49(3):e73-5. Singapore Med J. 2008. PMID: 18362991
-
Primary stage I-IIE non-Hodgkin's lymphoma of uterine cervix and upper vagina: evidence for a conservative approach in a study on three patients.Gynecol Oncol. 2005 Apr;97(1):214-8. doi: 10.1016/j.ygyno.2004.07.065. Gynecol Oncol. 2005. PMID: 15790461
-
A case of extra-nodal lymphoma presenting as post-menopausal bleeding.J Obstet Gynaecol. 2003 May;23(3):321-2. doi: 10.1080/01443610310000106019. J Obstet Gynaecol. 2003. PMID: 12918486 No abstract available.
-
Primary diffuse large B cell lymphoma of Uterine Cervix: Treatment outcomes of a rare entity with literature review.Cancer Rep (Hoboken). 2020 Oct;3(5):e1264. doi: 10.1002/cnr2.1264. Epub 2020 Aug 6. Cancer Rep (Hoboken). 2020. PMID: 32761885 Free PMC article. Review.
-
A primitive lymphoma of the uterine cervix. Case report.Eur J Gynaecol Oncol. 1991;12(2):107-12. Eur J Gynaecol Oncol. 1991. PMID: 2055224 Review.
Cited by
-
A Case of Primary Uterina Lymphoma Presenting with Bleeding, Pelvic Pain, and Dysmenorrhea.Case Rep Obstet Gynecol. 2018 Jan 22;2018:5065738. doi: 10.1155/2018/5065738. eCollection 2018. Case Rep Obstet Gynecol. 2018. PMID: 29607236 Free PMC article.
-
Secondary Involvement of the Uterine Cervix by Nongynecologic Neoplasms: A Detailed Clinicopathologic Analysis.Am J Surg Pathol. 2020 Dec;44(12):1699-1711. doi: 10.1097/PAS.0000000000001578. Am J Surg Pathol. 2020. PMID: 32910021 Free PMC article.
-
Primary T-Cell Non-Hodgkin Lymphoma of the Vagina.Case Rep Obstet Gynecol. 2015;2015:893083. doi: 10.1155/2015/893083. Epub 2015 May 26. Case Rep Obstet Gynecol. 2015. PMID: 26101677 Free PMC article.
-
Postcoital bleeding: a review on etiology, diagnosis, and management.Obstet Gynecol Int. 2014;2014:192087. doi: 10.1155/2014/192087. Epub 2014 Jun 17. Obstet Gynecol Int. 2014. PMID: 25045355 Free PMC article. Review.
-
Primary diffuse large B cell lymphoma of the uterine cervix successfully treated by combined chemotherapy alone: A case report.Medicine (Baltimore). 2017 May;96(19):e6846. doi: 10.1097/MD.0000000000006846. Medicine (Baltimore). 2017. PMID: 28489772 Free PMC article.