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. 2005 Mar 18;23(17-18):2395-8.
doi: 10.1016/j.vaccine.2005.01.017.

Development of a therapeutic vaccine for HSV-2

Nancy A Hosken  1
Affiliations

Development of a therapeutic vaccine for HSV-2

Nancy A Hosken. Vaccine. .

Abstract

A therapeutic vaccine for genital herpes is clearly needed. Vaccines recently developed for HSV-2 in humans have been aimed at eliciting CD4+ T cell responses and neutralizing antibody responses to two HSV-2 glycoproteins (gB and gD). These vaccines have had no therapeutic effect against HSV-2 in human clinical trials. To enable development of an efficacious vaccine, Corixa Corporation has made a major effort to identify novel antigens that can be recognized by human HSV-2-specific CD8+ and CD4+ T cells. Corixa Corporation's proprietary adjuvants and delivery systems, when combined with appropriate antigens, may allow the development of an effective therapeutic vaccine for HSV-2.

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