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Case Reports
. 2005 Mar;146(3):423-5.
doi: 10.1016/j.jpeds.2004.11.022.

Fatal varicella associated with selective natural killer cell deficiency

Amos Etzioni  1 , Celine Eidenschenk, Rina Katz, Rafeal Beck, Jean Laurent Casanova, Shimon Pollack
Affiliations
Case Reports

Fatal varicella associated with selective natural killer cell deficiency

Amos Etzioni et al. J Pediatr. 2005 Mar.

Abstract

A 2-year-old girl with recurrent severe varicella infections had a fatal outcome. Studies of cellular and humoral immunity were normal. No natural killer (NK) cells were detected, and NK activity was markedly decreased. The interleukin (IL)15/IL15R signaling pathway was intact. This case emphasizes the role of NK cells in controlling herpes viral infection.

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