Combinatorial libraries - from solution to 2D microarrays
- PMID: 15756311
- DOI: 10.1039/b415847d
Combinatorial libraries - from solution to 2D microarrays
Abstract
Enzymatic modifications of split and mix libraries were followed by "pulling down" onto a 2-dimensional DNA microarray, via PNA tagging; this allowed complete library interrogation of all members of the split and mix library.
Similar articles
-
PNA encoding (PNA=peptide nucleic acid): from solution-based libraries to organized microarrays.Chemistry. 2005 Nov 18;11(23):6792-801. doi: 10.1002/chem.200500305. Chemistry. 2005. PMID: 16038006
-
PNA-encoded protease substrate microarrays.Chem Biol. 2004 Oct;11(10):1351-60. doi: 10.1016/j.chembiol.2004.07.015. Chem Biol. 2004. PMID: 15489162
-
Assembly of PNA-tagged small molecules, peptides, and carbohydrates onto DNA templates: programming the combinatorial pairing and inter-ligand distance.Methods Mol Biol. 2014;1050:95-110. doi: 10.1007/978-1-62703-553-8_8. Methods Mol Biol. 2014. PMID: 24297353
-
Chemistry on nucleic acid templates.Chem Biodivers. 2010 Oct;7(10):2581-615. doi: 10.1002/cbdv.201000108. Chem Biodivers. 2010. PMID: 20963776 Review. No abstract available.
-
The impact of combinatorial chemistry on drug discovery.Curr Opin Drug Discov Devel. 2003 Jul;6(4):494-508. Curr Opin Drug Discov Devel. 2003. PMID: 12951813 Review.
Cited by
-
Fluorescent DNA-based enzyme sensors.Chem Soc Rev. 2011 Dec;40(12):5756-70. doi: 10.1039/c0cs00162g. Epub 2011 Feb 2. Chem Soc Rev. 2011. PMID: 21290032 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources