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Review
. 1992 Feb;14(2):105-11.
doi: 10.1002/bies.950140206.

Accessory protein function in the DNA polymerase III holoenzyme from E. coli

M O'Donnell  1
Affiliations
Review

Accessory protein function in the DNA polymerase III holoenzyme from E. coli

M O'Donnell. Bioessays. 1992 Feb.

Abstract

DNA polymerases which duplicate cellular chromosomes are multiprotein complexes. The individual functions of the many proteins required to duplicate a chromosome are not fully understood. The multiprotein complex which duplicates the Escherichia coli chromosome, DNA polymerase III holoenzyme (holoenzyme), contains a DNA polymerase subunit and nine accessory proteins. This report summarizes our current understanding of the individual functions of the accessory proteins within the holoenzyme, lending insight into why a chromosomal replicase needs such a complex structure.

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