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Comparative Study
. 1992 Apr 30;184(2):859-64.
doi: 10.1016/0006-291x(92)90669-c.

Molecular cloning and sequencing of cDNA encoding urinary stone protein, which is identical to osteopontin

K Kohri  1 , Y Suzuki, K Yoshida, K Yamamoto, N Amasaki, T Yamate, T Umekawa, M Iguchi, H Sinohara, T Kurita
Affiliations
Comparative Study

Molecular cloning and sequencing of cDNA encoding urinary stone protein, which is identical to osteopontin

K Kohri et al. Biochem Biophys Res Commun. .

Abstract

We have sequenced a cDNA of urinary stone protein. cDNA sequences show complete homology between urinary stone protein and human osteopontin (bone sialoprotein) (nucleotides 265-886 and 1183-1424). Osteopontin is a recently discovered bone matrix protein which has been implicated in mediating mineral formation within bone extracellular matrix. This result shows that osteopontin is presumably involved in stone formation as stone matrix.

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