Molecular defects in the growth hormone-IGF axis
- PMID: 15758538
- DOI: 10.1007/BF02760700
Molecular defects in the growth hormone-IGF axis
Abstract
Many previously uncharacterized cases of poor growth in children, i.e. idiopathic short stature, are now attributable to genetic defects in the GH-IGF-1 axis. This paper will provide an overview of the clinical findings of patients identified with various genetic defects of the GH/IGF-1 axis with an emphasis on the more recently described syndromes.
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