doi: 10.1021/ol0501525.
Three-component synthesis of alpha,beta-cyclopropyl-gamma-amino acids
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- PMID: 15760158
- DOI: 10.1021/ol0501525
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Three-component synthesis of alpha,beta-cyclopropyl-gamma-amino acids
Org Lett.
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Abstract
[reaction: see text] The multicomponent coupling of alkenylzirconocenes with N-diphenylphosphinoyl imines provides rapid access to functionalized C-cyclopropylalkylamides which have been readily transformed into alpha,beta-cyclopropyl-gamma-amino acids. These novel scaffolds are thus accessible in ca. 8 steps from commercially available alkynes.
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