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Clinical Trial
. 2005 Jun;20(6):1632-5.
doi: 10.1093/humrep/deh822. Epub 2005 Mar 10.

Endometrial polyps and their implication in the pregnancy rates of patients undergoing intrauterine insemination: a prospective, randomized study

Tirso Pérez-Medina  1 , José Bajo-Arenas, Francisco Salazar, Teresa Redondo, Luis Sanfrutos, Pilar Alvarez, Virginia Engels
Affiliations
Clinical Trial

Endometrial polyps and their implication in the pregnancy rates of patients undergoing intrauterine insemination: a prospective, randomized study

Tirso Pérez-Medina et al. Hum Reprod. 2005 Jun.

Abstract

Background: It was our intention to determine whether hysteroscopic polypectomy before intrauterine insemination (IUI) achieved better pregnancy outcomes than no intervention.

Methods: A total of 215 infertile women from the infertility unit of a university tertiary hospital with ultrasonographically diagnosed endometrial polyps (EP) undergoing IUI were randomly allocated to one of two pretreatment groups using an opaque envelope technique with assignment determined by a random number table. Hysteroscopic polypectomy was performed in the study group. Diagnostic hysteroscopy and polyp biopsy was performed in the control group.

Results: Total pregnancy rates and time for success in both groups after four IUI cycles were compared by means of contingency tables and life-table analysis. A total of 93 pregnancies occurred, 64 in the study group and 29 in the control group. Women in the study group had a better possibility of becoming pregnant after polypectomy, with a relative risk of 2.1 (95% confidence interval 1.5-2.9). Pregnancies in the study group were obtained before the first IUI in 65% of cases.

Conclusions: These data suggest that hysteroscopic polypectomy before IUI is an effective measure.

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