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Comparative Study
. 2005 Mar 7;11(9):1287-91.
doi: 10.3748/wjg.v11.i9.1287.

Tumor angiogenesis and dynamic CT in colorectal carcinoma: radiologic-pathologic correlation

Zi-Ping Li  1 , Quan-Fei Meng, Can-Hui Sun, Da-Sheng Xu, Miao Fan, Xu-Feng Yang, Dong-Ying Chen
Affiliations
Comparative Study

Tumor angiogenesis and dynamic CT in colorectal carcinoma: radiologic-pathologic correlation

Zi-Ping Li et al. World J Gastroenterol. .

Abstract

Aim: To investigate the correlation between microvessel density and spiral CT perfusion imaging in colorectal carcinoma.

Methods: Thirty-seven patients, with histologically proven colorectal carcinoma, underwent water enema spiral CT scan. The largest axial surface of the primary tumor was searched on unenhanced spiral CT images. At this level, the enhanced dynamic scan series was acquired. Time-density curves (TDC) were created from the region of interest drawn over the tumor, target artery by Toshiba Xpress/SX spiral CT with perfusion functional software. Then the perfusion was calculated. Microvessel density (MVD) was evaluated using immunohistochemical staining of surgical specimens with anti-CD34, and then MVD was correlated with perfusion.

Results: MVD of colorectal carcinomas was 33.11-173.44, mean 87.28, and perfusion was 15.60-64.80 mL/min/100 g, mean 39.74 mL/min/100 g. MVD and perfusion were not associated with invasive depth, metastasis and disease stage, and they all decreased with increasing Dukes' stage, but no significant correlation was found between them (r = 0.18, P = 0.29).

Conclusion: There is no significant correlation between MVD and perfusion. Neovascularizaton and perfusion are highly presented in early colorectal carcinoma. CT perfusion imaging may be more suited for assessing tumorigenesis in colorectal carcinoma than histological MVD technique.

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Figures

Figure 1
Figure 1
Rectal carcinoma. A: Target plane of CT perfusion indicates invasive nodule (arrow) and ROI (white round region); B: Corresponding section of specimen shows invasive nodule (five corner star) and examined area (white round region).
Figure 2
Figure 2
High microvessel density, stained by CD34 (magnification, ×100).
Figure 3
Figure 3
Low microvessel density with high PF. A: many large vessels with low microvessel density (magnification, ×100); B: Perfusion image shows obvious enhancement of colon lesion with high PF (44.4 mL/min/100 g).
Figure 4
Figure 4
mean±SD for PF for each Dukes’ stage.
See this image and copyright information in PMC

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References

    1. Hawighorst H, Knapstein PG, Knopp MV, Weikel W, Brix G, Zuna I, Schönberg SO, Essig M, Vaupel P, van Kaick G. Uterine cervical carcinoma: comparison of standard and pharmacokinetic analysis of time-intensity curves for assessment of tumor angiogenesis and patient survival. Cancer Res. 1998;58:3598–3602. - PubMed
    1. Bossi P, Viale G, Lee AK, Alfano R, Coggi G, Bosari S. Angiogenesis in colorectal tumors: microvessel quantitation in adenomas and carcinomas with clinicopathological correlations. Cancer Res. 1995;55:5049–5053. - PubMed
    1. Hermans R, Lambin P, Van der Goten A, Van den Bogaert W, Verbist B, Weltens C, Delaere PR. Tumoural perfusion as measured by dynamic computed tomography in head and neck carcinoma. Radiother Oncol. 1999;53:105–111. - PubMed
    1. Miles KA, Hayball MP, Dixon AK. Measurement of human pancreatic perfusion using dynamic computed tomography with perfusion imaging. Br J Radiol. 1995;68:471–475. - PubMed
    1. Weidner N. Intratumor microvessel density as a prognostic factor in cancer. Am J Pathol. 1995;147:9–19. - PMC - PubMed

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