Serum vascular endothelial growth factor165 levels and uterine fibroid volume

Abstract

Background: Vascular endothelial growth factor165 (VEGF165) demonstrates increased expression in uterine fibroids. This study aimed to investigate the relationship between serum VEGF165 levels and uterine fibroid volume.

Methods: On a prospective observational basis, 80 women with symptomatic uterine fibroids underwent hysterectomy. Uterine weight was determined after hysterectomy. Six hours before and 48 h after hysterectomy, serum VEGF165 levels were measured using an enzyme-linked immunosorbent assay.

Results: Logistic regression analysis showed no correlation between serum VEGF165 levels and uterine weight (r=0.0037; P>0.05). The mean serum VEGF165 level declined significantly from 716.31+/-457.99 to 581.81+/-403.32 pg/mL after hysterectomy (P<0.0001). Controlling for age, body mass index, uterine weight, proliferative or secretory phase, and parity, only parous patients (n=58) were found to have significantly decreased serum VEGF165 levels after hysterectomy (P=0.000035), in contrast to nulliparous patients (n=22; P=0.15).

Conclusions: Serum VEGF165 levels do not correlate with uterine fibroid volume, but demonstrate a significant decrease after hysterectomy. The decrease in serum VEGF165 levels after hysterectomy was significant in parous but not in nulliparous patients with uterine fibroids. Serum VEGF165 levels may not predict uterine fibroid development.