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. 2005 May;62(5):745-50.
doi: 10.1016/j.apradiso.2004.11.003. Epub 2004 Dec 22.

Labeling and biodistribution of different particle materials for radioembolization therapy with 188Re

Gerd Wunderlich  1 , Jörg Pinkert, Michael Stintz, Jörg Kotzerke
Affiliations

Labeling and biodistribution of different particle materials for radioembolization therapy with 188Re

Gerd Wunderlich et al. Appl Radiat Isot. 2005 May.

Abstract

Radioembolization of tumors after selective catheterization has been proven to be an effective therapy in nuclear medicine. The goal of the study was to evaluate the (188)Re labeling and in vitro and in vivo stability of several representative non-degradable polymeric microspheres and biodegradable particles. The biodistribution after i.v. injection in Wistar rats revealed excellent in vivo stability with low uptake in the non-target tissues over 48 h for some polymeric particles and especially for biodegradable human serum albumin microspheres.

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