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Review
. 2005 Mar 11;120(5):569-70.
doi: 10.1016/j.cell.2005.02.028.

Reduced replication: a call to ARMS

Michael A Resnick  1
Affiliations
Free article
Review

Reduced replication: a call to ARMS

Michael A Resnick. Cell. .
Free article

Abstract

In this issue of Cell, Lemoine et al. monitor chromosome instability in yeast cells with reduced levels of an essential replicative DNA polymerase. The authors identify a hotspot for chromosome aberrations reminiscent of fragile sites in human cells. This hotspot is composed of inverted Ty elements, which lead to a double-strand break under conditions of limited replication.

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