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Clinical Trial
. 2005 Apr;93(1):95-105.
doi: 10.1016/j.bandl.2004.08.004.

Improved picture naming in chronic aphasia after TMS to part of right Broca's area: an open-protocol study

Margaret A Naeser  1 , Paula I Martin, Marjorie Nicholas, Errol H Baker, Heidi Seekins, Masahito Kobayashi, Hugo Theoret, Felipe Fregni, Jose Maria-Tormos, Jacquie Kurland, Karl W Doron, Alvaro Pascual-Leone
Affiliations
Clinical Trial

Improved picture naming in chronic aphasia after TMS to part of right Broca's area: an open-protocol study

Margaret A Naeser et al. Brain Lang. 2005 Apr.

Abstract

Functional imaging studies with nonfluent aphasia patients have observed "over-activation" in right (R) language homologues. This may represent a maladaptive strategy; suppression may result in language improvement. We applied slow, 1 Hz repetitive transcranial magnetic stimulation (rTMS) to an anterior portion of R Broca's homologue daily, for 10 days in four aphasia patients who were 5-11 years poststroke. Significant improvement was observed in picture naming at 2 months post-rTMS, with lasting benefit at 8 months in three patients. This preliminary, open trial suggests that rTMS may provide a novel treatment approach for aphasia by possibly modulating the distributed, bi-hemispheric language network.

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