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Review
. 2005 Mar 16;293(11):1367-73.
doi: 10.1001/jama.293.11.1367.

The prospect of silencing disease using RNA interference

Premlata Shankar  1 , N Manjunath, Judy Lieberman
Affiliations
Review

The prospect of silencing disease using RNA interference

Premlata Shankar et al. JAMA. .

Abstract

The discovery of RNA interference (RNAi), an endogenous cellular gene-silencing mechanism, has already provided a powerful tool for basic science researchers to study gene function. The subsequent finding that RNAi also operates in mammalian cells has generated excitement regarding potential therapeutic applications. In this article we discuss the basic mechanism of RNAi and the therapeutic opportunities and obstacles for harnessing RNAi for therapy of human disease.

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