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. 2005 Apr 15;191(8):1221-4.
doi: 10.1086/428911. Epub 2005 Mar 8.

Prevalence of reovirus-specific antibodies in young children in Nashville, Tennessee

Jennifer H Tai  1 , John V Williams, Kathryn M Edwards, Peter F Wright, James E Crowe Jr, Terence S Dermody
Affiliations

Prevalence of reovirus-specific antibodies in young children in Nashville, Tennessee

Jennifer H Tai et al. J Infect Dis. .

Abstract

Although reovirus infections are thought to be common in adults, there have been few assessments of the seroprevalence of reovirus in young children. We developed an indirect enzyme-linked immunosorbent assay to measure levels of total antireovirus immunoglobulin A, G, and M in serum specimens collected from otherwise healthy infants and children (1 month to 5 years of age) in Nashville, Tennessee. Of the 272 serum specimens evaluated, 64 (23.5%) tested positive for reovirus-specific antibodies. We observed an age-dependent increase in reovirus-specific antibodies in children 1 year of age and older, peaking at 50.0% in children 5-6 years of age. These findings suggest that reovirus infections are common during early childhood.

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Figures

Figure 1
Figure 1
Prevalence of reovirus-specific antibodies by age group. Two-hundred seventy-two serum specimens collected from young children were analyzed, by indirect ELISA, for the presence of total IgA, IgG, and IgM specific for type 3 reovirus. The no. of positive specimens and the total no. of specimens for each age group are shown. The error bars represent 95% confidence intervals for each age group. Fisher’s exact test was used to determine statistical significance of associations
Figure 2
Figure 2
Titers of reovirus-specific antibodies in seropositive subjects, by age group. End-point titer was determined for 64 serum specimens that tested positive for reovirus-specific antibodies by indirect ELISA. Each diamond represents the log2 reciprocal titer for an individual sample obtained from a unique study participant. The horizontal line for each age group designates the geometric mean titer (GMT) for that group. GMTs are as follows: 1:215 for 0–3 months of age, 1:160 for 3–6 months of age, 1:438 for 1–2 years of age, 1:586 for 2–3 years of age, 1:718 for 3–4 years of age, 1:691 for 4–5 years of age, and 1:527 for 5–6 years of age
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References

    1. Tyler KL. Mammalian reoviruses. In: Knipe DM, Howley PM, Griffin DE, et al., editors. Fields virology. 4th ed. Vol 2. Philadelphia: Lippincott Williams & Wilkins; 2001. pp. 1729–45.
    1. Jackson GG, Muldoon RL, Cooper RS. Reovirus type 1 as an etiologic agent of the common cold. J Clin Invest. 1961;40:1051.
    1. Rosen L, Evans HE, Spickard A. Reovirus infections in human volunteers. Am J Hyg. 1963;77:29–37. - PubMed
    1. Tyler KL, Barton ES, Ibach ML, et al. Isolation and molecular characterization of a novel type 3 reovirus from a child with meningitis. J Infect Dis. 2004;189:1664–75. - PubMed
    1. Tyler KL, Sokol RJ, Oberhaus SM, et al. Detection of reovirus RNA in hepatobiliary tissues from patients with extrahepatic biliary atresia and choledochal cysts. Hepatology. 1998;27:1475–82. - PubMed

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