Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1971 Sep 1;134(3 Pt 1):681-92.
doi: 10.1084/jem.134.3.681.

Abnormal development of the thymus in "nude" mice

H H Wortis, S Nehlsen, J J Owen

Abnormal development of the thymus in "nude" mice

H H Wortis et al. J Exp Med. .

Abstract

Nude mice bearing grafts of normal thymus reject skin grafts and have low, but higher than usual, lymphocyte counts. Nude bone marrow can successfully repopulate the thymus and thymus-derived areas of lethelly irradiated recipient mice. Attempts to reconstitute nude mice with normal fetal liver failed. The so-called thymic rudiment of nude mice when grafted to normal mice did not develop thymocytes. These experiments show that nude mice suffer from a defect of the epithelial portion of the thymus rather than of the precursors of thymocytes.

PubMed Disclaimer

References

    1. Genet Res. 1966 Dec;8(3):295-309 - PubMed
    1. Nature. 1968 Jan 27;217(5126):370-1 - PubMed
    1. J Exp Med. 1969 Feb 1;129(2):431-42 - PubMed
    1. Clin Exp Immunol. 1969 Jun;4(6):637-44 - PubMed
    1. Immunology. 1970 Jun;18(6):931-42 - PubMed