Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1971 Sep 1;134(3 Pt 1):741-50.
doi: 10.1084/jem.134.3.741.

The compartmentalization of antigen-reactive lymphocytes in desensitized guinea pigs

S F Schlossman, H A Levin, R E Rocklin, J R David

The compartmentalization of antigen-reactive lymphocytes in desensitized guinea pigs

S F Schlossman et al. J Exp Med. .

Abstract

A single injection of epsilon,DNP-Lys(7-10) can render previously sensitized guinea pigs specifically unreactive to subsequent intradermal challenge with that antigen. Antigen-reactive lymphocytes, as assayed by macrophage-migration in-inhibition or thymidine incorporation, were depleted from the peritoneal exudates of those animals. In contrast, it was intriguing to find that lymph node lymphocytes from such animals responded normally in the antigen-induced thymidine incorporation assay. These studies demonstrate a compartmentalization of antigen-reactive lymphocytes in desensitized animals which may account for the short-lived nature of this phenomenon.

PubMed Disclaimer

References

    1. J Immunol. 1967 Jul;99(1):111-4 - PubMed
    1. J Exp Med. 1969 Nov 1;130(5):1031-45 - PubMed
    1. Biochemistry. 1965 Aug;4(8):1638-45 - PubMed
    1. J Immunol. 1969 Apr;102(4):804-11 - PubMed
    1. J Exp Med. 1968 Dec 1;128(6):1451-9 - PubMed