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Review
. 2005 Jun;145(3):271-3.
doi: 10.1038/sj.bjp.0706202.

Megakaryocyte apoptosis: sorting out the signals

Affiliations
Review

Megakaryocyte apoptosis: sorting out the signals

Michael P Gordge. Br J Pharmacol. 2005 Jun.
No abstract available

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Figures

Figure 1
Figure 1
PGI2 opposes the caspase activation and nuclear changes evident during NO-mediated apoptosis of MKs. It is not yet clear whether prostacylin exerts a similar influence on proplatelet formation and platelet release.

Comment on

References

    1. AVECILLA S.T., HATTORI K., HEISSIG B., TEJADA R., LIAO F., SHIDO K., JIN D.K., DIAS S., ZHANG F., HARTMAN T.E., HACKETT N.R., CRYSTAL R.G., WITTE L., HICKLIN D.J., BOHLEN P., EATON D., LYDEN D., DE SAUVAGE F., RAFII S. Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. Nat. Med. 2004;10:64–71. - PubMed
    1. BATTINELLI E., LOSCALZO J. Nitric oxide induces apoptosis in megakaryocytic cell lines. Blood. 2000;95:3451–3459. - PubMed
    1. BATTINELLI E., WILLOUGHBY S.R., FOXALL T., VALERI C.R., LOSCALZO J. Induction of platelet formation from megakaryocytoid cells by nitric oxide. Proc. Natl. Acad. Sci. U.S.A. 2001;98:14458–14463. - PMC - PubMed
    1. BUNTING S., WIDMER R., LIPARI T., RANGELL L., STEINMETZ H., CARVER-MOORE K., MOORE M.W., KELLER G.A., DE SAUVAGE F.J. Normal platelets and megakaryocytes are produced in vivo in the absence of thrombopoietin. Blood. 1997;90:3423–3429. - PubMed
    1. CLARKE M.C., SAVILL J., JONES D.B., NOBLE B.S., BROWN S.B. Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death. J. Cell Biol. 2003;160:577–587. - PMC - PubMed