Review
doi: 10.1016/j.ceb.2005.02.009.
Linking Rap to cell adhesion
Affiliations
- PMID: 15780587
- DOI: 10.1016/j.ceb.2005.02.009
Item in Clipboard
Review
Linking Rap to cell adhesion
Curr Opin Cell Biol.
2005 Apr.
Abstract
The small GTPase Rap1 is involved in several aspects of cell adhesion, including integrin-mediated cell adhesion and cadherin-mediated cell junction formation. Recently, several effector proteins for Rap1 have been identified providing a clear link between Rap1 and actin dynamics. Furthermore, evidence is accumulating that Rap1 functions in the spatial and temporal control of cell polarity.
Similar articles
-
RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation.Mol Cell Biol. 2007 Jun;27(11):4070-81. doi: 10.1128/MCB.02011-06. Epub 2007 Apr 2. Mol Cell Biol. 2007. PMID: 17403904 Free PMC article.
-
RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1.Nat Immunol. 2003 Aug;4(8):741-8. doi: 10.1038/ni950. Epub 2003 Jul 6. Nat Immunol. 2003. PMID: 12845325
-
Rap1: a key regulator in cell-cell junction formation.J Cell Sci. 2007 Jan 1;120(Pt 1):17-22. doi: 10.1242/jcs.03306. J Cell Sci. 2007. PMID: 17182900 Review.
-
Regulation of lymphocyte adhesion and migration by the small GTPase Rap1 and its effector molecule, RAPL.Immunol Lett. 2004 Apr 30;93(1):1-5. doi: 10.1016/j.imlet.2004.02.008. Immunol Lett. 2004. PMID: 15134891 Review.
-
Activation of Rac by cadherin through the c-Src-Rap1-phosphatidylinositol 3-kinase-Vav2 pathway.Oncogene. 2006 Jan 5;25(1):8-19. doi: 10.1038/sj.onc.1209010. Oncogene. 2006. PMID: 16170364
Cited by
-
Regulation of actin cytoskeleton by Rap1 binding to RacGEF1.Mol Cells. 2012 Jul;34(1):71-6. doi: 10.1007/s10059-012-0097-z. Epub 2012 May 25. Mol Cells. 2012. PMID: 22644079 Free PMC article.
-
Adapter Protein RapGEF1 Is Required for ERK1/2 Signaling in Response to Elevated Phosphate in Vascular Smooth Muscle Cells.J Vasc Res. 2021;58(5):277-285. doi: 10.1159/000516044. Epub 2021 May 5. J Vasc Res. 2021. PMID: 33951626 Free PMC article.
-
Spatial regulation of cyclic AMP-Epac1 signaling in cell adhesion by ERM proteins.Mol Cell Biol. 2010 Nov;30(22):5421-31. doi: 10.1128/MCB.00463-10. Epub 2010 Sep 20. Mol Cell Biol. 2010. PMID: 20855527 Free PMC article.
-
Ras-Dependent Cell Fate Decisions Are Reinforced by the RAP-1 Small GTPase in Caenorhabditiselegans.Genetics. 2018 Dec;210(4):1339-1354. doi: 10.1534/genetics.118.301601. Epub 2018 Sep 26. Genetics. 2018. PMID: 30257933 Free PMC article.
-
Loss of TTC17 promotes breast cancer metastasis through RAP1/CDC42 signaling and sensitizes it to rapamycin and paclitaxel.Cell Biosci. 2023 Mar 9;13(1):50. doi: 10.1186/s13578-023-01004-8. Cell Biosci. 2023. PMID: 36895029 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
