doi: 10.1016/j.bmcl.2005.02.049.
18F-labeled sufentanil for PET-imaging of mu-opioid receptors
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- PMID: 15780604
- DOI: 10.1016/j.bmcl.2005.02.049
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18F-labeled sufentanil for PET-imaging of mu-opioid receptors
Bioorg Med Chem Lett.
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Abstract
The synthesis of an (18)F-labeled sufentanil analogue with apparent high mu-opioid receptor selectivity is reported. Intravenous injection of N-[4-(methoxymethyl)-1-[2-(2-thienyl)ethyl]-4-piperidinyl]-N-phenyl-2-(+/-)-[(18)F]fluoropropan-amide in mice resulted in high brain uptake and a regional brain activity distribution corresponding to the mu-opioid receptor expression pattern. The developed ligand is a promising tracer for extended protocols in mu-opioid receptor mapping and quantitation with positron emission tomography.
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