Filling the gaps in replication restart pathways
- PMID: 15780929
- DOI: 10.1016/j.molcel.2005.03.001
Filling the gaps in replication restart pathways
Abstract
Recent work by clarifies two mechanisms of replication fork assembly in E. coli: in vitro, the presence of a leading nascent strand dictates a PriA/B DnaT-dependent mechanism, whereas a gapped fork specifies PriC-mediated restart.
Comment on
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The disposition of nascent strands at stalled replication forks dictates the pathway of replisome loading during restart.Mol Cell. 2005 Mar 4;17(5):733-43. doi: 10.1016/j.molcel.2005.01.019. Mol Cell. 2005. PMID: 15749022
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