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Review
. 2005 Mar 21;201(6):833-6.
doi: 10.1084/jem.20050339.

Signaling for NKT cell development: the SAP-FynT connection

Christine Borowski  1 , Albert Bendelac
Affiliations
Review

Signaling for NKT cell development: the SAP-FynT connection

Christine Borowski et al. J Exp Med. .

Abstract

New studies demonstrate a critical role for the adaptor protein SAP (SLAM-associated protein) during NKT cell development. By connecting homotypic SLAM family receptor interactions with the FynT Src kinase, SAP may integrate a set of long-standing yet seemingly disparate observations characterizing NKT cell development. In fact, SAP-dependent signaling may underlie the development of multiple unconventional T cell lineages whose thymic selection relies on homotypic interactions between hematopoietic cells.

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Figures

Figure 1.
Figure 1.
Potential scheme of SAP-dependent NKT cell selection. Homotypic interactions between Vα14i TCR+ and CD1d/iGb3+ cortical CD4+CD8+ double positive (DP) thymocyes allow simultaneous SAP-dependent homotypic interactions between unidentified SLAM family members. Interactions between CD8 and CD1d might also occur. Heterotypic interactions between conventional (non-Vα14i) TCR+ DP thymocytes and MHC–peptide+ thymic epithelial cells allow CD8–MHC class I interactions.
Figure 2.
Figure 2.
Potential signaling pathways triggered by ligation of SLAM family members. P, phosphorylation.
See this image and copyright information in PMC

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