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Review
. 2005 Mar 21;201(6):841-3.
doi: 10.1084/jem.20050354.

Identifying genes that regulate bone remodeling as potential therapeutic targets

Stephen M Krane  1
Affiliations
Review

Identifying genes that regulate bone remodeling as potential therapeutic targets

Stephen M Krane. J Exp Med. .

Abstract

Bone remodeling, a coupled process involving bone resorption and formation, is initiated by mechanical signals and is controlled by local and systemic factors that regulate osteoblast and osteoclast differentiation and function. An excess of resorption over formation leads to the bone loss and increased propensity to fracture that is characteristic of osteoporosis. A newly described inhibitor of osteoblast differentiation, Ciz, interferes with bone morphogenic protein signaling. As a consequence, Ciz-deficient mice develop increased bone mass.

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Figures

Figure 1.
Figure 1.
Cells and ligands in skeletal remodeling. Interactions in bone formation and resorption among osteoblasts and osteoclasts and some factors that modulate their differentiation and function. OPG, osteoprotegerin.
See this image and copyright information in PMC

References

    1. Rodan, G.A., L.G. Raisz, and J.P. Bilezikian. 2002. Pathophysiology of osteoporosis. Principles of Bone Biology. J.P. Bilezikian, L.G. Raisz, and G.A. Rodan, editors. San Diego, Academic Press. 1275–1289.
    1. Lanyon, L., and T. Skerry. 2001. Postmenopausal osteoporosis as a failure of bone's adaptation to functional loading: a hypothesis. J. Bone Miner. Res. 16:1937–1947. - PubMed
    1. Delmas, P.D. 2000. How does antiresorptive therapy decrease the risk of fracture in women with osteoporosis? Bone. 27:1–3. - PubMed
    1. Neer, R.M., C.D. Arnaud, J.R. Zanchetta, R. Prince, G.A. Gaich, J.Y. Reginster, A.B. Hodsman, E.F. Eriksen, S. Shalom, H.K. Genant, O. Wang, and B.H. Mitlak. 2001. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N. Engl. J. Med. 344:1434–1441. - PubMed
    1. Morinobu, M., T. Nakamoto, K. Hino, K. Tsuji, Z.-J. Shen, K. Nakashima, A. Nifuji, H. Yamamoto, H. Hirai, and M. Noda. 2005. The nucleocytoplasmic shuttling protein CIZ reduces adult bone mass by inhibiting bone morphogenetic protein-induced bone formation. J. Exp. Med. 201:961–970. - PMC - PubMed