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Comparative Study
. 2005 Mar 22;64(6):1086-7.
doi: 10.1212/01.WNL.0000154639.35941.21.

Incidence of seizures in patients with multiple sclerosis treated with intrathecal baclofen

S U Schuele  1 , C Kellinghaus, S J Shook, N Boulis, F A Bethoux, T Loddenkemper
Affiliations
Comparative Study

Incidence of seizures in patients with multiple sclerosis treated with intrathecal baclofen

S U Schuele et al. Neurology. .

Abstract

Oral and intrathecal baclofen (ITB) have been associated with epileptic seizures. The authors observed a higher incidence of epileptic seizures in 99 patients with multiple sclerosis (MS) treated with ITB vs a matched control group (7% vs 1%, p < 0.05). Three patients with MS on ITB developed status epilepticus. Seizures were often associated with additional triggering factors.

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