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. 2005 Mar 30;127(12):4158-9.
doi: 10.1021/ja042829+.

Cell-permeable near-infrared fluorogenic substrates for imaging beta-lactamase activity

Bengang Xing  1 , Ashot Khanamiryan, Jianghong Rao
Affiliations

Cell-permeable near-infrared fluorogenic substrates for imaging beta-lactamase activity

Bengang Xing et al. J Am Chem Soc. .

Erratum in

  • J Am Chem Soc. 2006 Feb 1;128(4):1394

Abstract

This communication describes a design of cell-permeable near-infrared fluorogenic substrates for imaging beta-lactamase expression in living mammalian cells. This design is based on fluorescence energy transfer resonance and utilizes a peracetylated d-glucosamine to facilitate the transport of the near-infrared probe across cell membranes. This new type of fluorogenic probe may also be applied to image gene expression in living animals.

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