Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2005 Apr;49(4):1593-6.
doi: 10.1128/AAC.49.4.1593-1596.2005.

Synergistic activities of fluconazole and voriconazole with terbinafine against four Candida species determined by checkerboard, time-kill, and Etest methods

Emilia Cantón  1 , Javier Pemán, Miguel Gobernado, Angel Viudes, Ana Espinel-Ingroff
Affiliations
Comparative Study

Synergistic activities of fluconazole and voriconazole with terbinafine against four Candida species determined by checkerboard, time-kill, and Etest methods

Emilia Cantón et al. Antimicrob Agents Chemother. 2005 Apr.

Abstract

The in vitro activities of fluconazole or voriconazole plus terbinafine were evaluated against 20 Candida isolates by the checkerboard, time-kill, and Etest methods. Synergism (C. albicans, C. glabrata, and C. tropicalis) and indifference (C. krusei) were observed. Correlation among methods was good. The Etest is a suitable method to determine drug interactions.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Afeltra, J., J. F. G. Meis, R. G. Vitale, J. W. Mouton, P. E. Verweij, and the Eurofung Network. 2002. In vitro activities of pentamidine, trimethoprim, and sulfonamides against Aspergillus species. Antimicrob. Agents Chemother. 46:2029-2031. - PMC - PubMed
    1. Andes, D., K. Marchillo, T. Stamstad, and R. Conklin. 2003. In vivo pharmacokinetics and pharmacodynamics of a new triazole, voriconazole, in a murine candidiasis model. Antimicrob. Agents Chemother. 47:3165-3169. - PMC - PubMed
    1. Balfour, J. A., and D. Faulds. 1992. Terbinafine. A review of its pharmacokinetic properties, and therapeutic potential in superficial mycosis. Drugs 43:259-284. - PubMed
    1. Barchiesi, F., L. Falconi Di Francesco, and G. Scalise. 1997. In vitro activities of terbinafine in combination with fluconazole and itraconazole against isolates of Candida albicans with reduced susceptibility to azoles. Antimicrob. Agents Chemother. 41:1812-1814. - PMC - PubMed
    1. Barchiesi, F., L. Falconi Di Francesco, P. Compagnucci, D. Arzeni, A. Giacometti, and G. Scalise. 1998. In-vitro interaction of terbinafine with amphotericin B, fluconazole and itraconazole against clinical isolates of Candida albicans. J. Antimicrob. Chemother. 41:59-65. - PubMed

Publication types