Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2005 Apr;49(4):1622-5.
doi: 10.1128/AAC.49.4.1622-1625.2005.

Pharmacokinetics of oral doxycycline during combination treatment of severe falciparum malaria

Paul N Newton  1 , Jean-François Chaulet, Alan Brockman, Wirongrong Chierakul, Arjen Dondorp, Ronatrai Ruangveerayuth, Sornchai Looareesuwan, Cyril Mounier, Nicholas J White
Affiliations
Clinical Trial

Pharmacokinetics of oral doxycycline during combination treatment of severe falciparum malaria

Paul N Newton et al. Antimicrob Agents Chemother. 2005 Apr.

Abstract

The pharmacokinetics of oral doxycycline administered at 200 mg every 24 h were investigated in 17 patients recovering from severe Plasmodium falciparum malaria. The data suggest that the doses of doxycycline currently recommended (circa 3.5 mg/kg of body weight daily) may not be optimal.

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Relationship between plasma doxycycline concentration and time after the first (solid line) and last (broken line) 200-mg doxycycline doses.
See this image and copyright information in PMC

References

    1. Anonymous. 1998. Drugs for parasitic infections. Med. Lett. 40:1-12. - PubMed
    1. Anonymous. 2000. British National Formulary No. 39. British Medical Association and the Royal Pharmaceutical Society of Great Britain, London, United Kingdom.
    1. Basco, L. K., and J. Le Bras. 1993. Activity in vitro of doxycycline against multidrug-resistant Plasmodium falciparum. Trans. R. Soc. Trop. Med. Hyg. 87:469-470. - PubMed
    1. Brockman, A., R. N. Price, M. van Vugt, D. G. Heppner, D. Walsh, P. Sooklo, T. Wimonwaltrawatee, S. Looareesuwan, N. J. White, and F. Nosten. 2000. Plasmodium falciparum antimalarial drug susceptibility on the northwestern border of Thailand during five years of extensive artesunate-mefloquine use. Trans. R. Soc. Trop. Med. Hyg. 94:537-544. - PMC - PubMed
    1. Chin, W., and R. Intraprasert. 1973. The evaluation of quinine alone or in combination with tetracycline and pyrimethamine against falciparum malaria in Thailand. Southeast Asian J. Trop. Med. Public Health 4:245-249. - PubMed

Publication types

MeSH terms

LinkOut - more resources