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. 2005 May;6(5):455-64.
doi: 10.1038/ni1185. Epub 2005 Mar 27.

TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation

Jennifer Hartt Meyers  1 , Sumone Chakravarti, David Schlesinger, Zsolt Illes, Hanspeter Waldner, Sarah E Umetsu, James Kenny, Xin Xiao Zheng, Dale T Umetsu, Rosemarie H DeKruyff, Terry B Strom, Vijay K Kuchroo
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Free article

TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation

Jennifer Hartt Meyers et al. Nat Immunol. 2005 May.
Free article

Abstract

The newly identified TIM family of proteins is associated with regulation of T helper type 1 (T(H)1) and T(H)2 immune responses. TIM-1 is genetically linked to asthma and is a receptor for hepatitis A virus, but the endogenous ligand of TIM-1 is not known. Here we show that TIM-4, which is expressed by antigen-presenting cells, is the ligand for TIM-1. In vivo administration of either soluble TIM-1-immunoglobulin (TIM-1-Ig) fusion protein or TIM-4-Ig fusion protein resulted in hyperproliferation of T cells, and TIM-4-Ig costimulated T cell proliferation mediated by CD3 and CD28 in vitro. These data suggest that the TIM-1-TIM-4 interaction is involved in regulating T cell proliferation.

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