Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2005 Apr;5(2):141-8.
doi: 10.1007/s11892-005-0042-z.

Nonobese diabetic mice and the genetics of diabetes susceptibility

Edward H Leiter  1
Affiliations
Review

Nonobese diabetic mice and the genetics of diabetes susceptibility

Edward H Leiter. Curr Diab Rep. 2005 Apr.

Abstract

The nonobese diabetic mouse spontaneously develops an autoimmune, T-cell-mediated type 1 diabetes (T1D). Common and rare alleles both within a diabetogenic major histocompatibility complex (MHC) and multiple non-MHC genes combine to impair normal communication between the innate and acquired immune system, leading to loss of immune tolerance. An understanding of how variable collections of genes interact with each other and with environmental cues offers important insights as to the complexities of T1D inheritance in humans.

PubMed Disclaimer

References

    1. J Immunol. 2004 Jan 15;172(2):871-9 - PubMed
    1. Nat Genet. 1993 Aug;4(4):404-9 - PubMed
    1. J Immunol. 1998 Feb 1;160(3):1472-8 - PubMed
    1. Diabetes. 2000 Sep;49(9):1612-6 - PubMed
    1. Am J Hum Genet. 2000 Jul;67(1):67-81 - PubMed

Publication types

MeSH terms

LinkOut - more resources