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Comment
. 2005 Apr 5;102(14):4933-4.
doi: 10.1073/pnas.0501417102. Epub 2005 Mar 28.

Sigma cascades in prokaryotic regulatory networks

Ferric C Fang  1
Affiliations
Comment

Sigma cascades in prokaryotic regulatory networks

Ferric C Fang. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
Sigma factor cascades in B. burgdorferi and Salmonella typhimurium. Alternative sigma factors can direct core RNA polymerase to transcribe specific gene subsets. (A)In B. burgdorferi, the alternative sigma factor σN appears to directly stimulate transcription of the rpoS gene encoding the sigma factor σS (9). Thus, activation of σN can enhance the expression of a large number of both σN- and σS-regulated genes (8). (B)In S. typhimurium, the alternative sigma factors σE, σH, and σS are linked by a more complex mechanism (15). The sigma factor σE stimulates transcription of the rpoH gene encoding the sigma factorσH which, in turn, stimulates transcription of the hfq gene encoding the RNA-binding protein Hfq. Binding of Hfq to the rpoS mRNA facilitates translation of the sigma factor σS. Regulatory interactions between sigma factors permit the integration of diverse environmental stimuli to trigger expression of a common stress response (in these instances, the σS regulon).
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