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. 2005 Apr 6;127(13):4594-5.
doi: 10.1021/ja0506509.

Asymmetric nickel-catalyzed Negishi cross-couplings of secondary alpha-bromo amides with organozinc reagents

Christian Fischer  1 , Gregory C Fu
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Asymmetric nickel-catalyzed Negishi cross-couplings of secondary alpha-bromo amides with organozinc reagents

Christian Fischer et al. J Am Chem Soc. .

Abstract

A Ni/Pybox catalyst achieves the asymmetric cross-coupling of secondary alpha-bromo amides with organozinc reagents. The process tolerates a variety of functional groups and affords the desired product in good yield and in high enantiomeric excess.

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