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Comment
. 2005 Mar 25;120(6):736-7.
doi: 10.1016/j.cell.2005.03.005.

Axis formation--beta-catenin catches a Wnt

Jason R Jessen  1 , Lila Solnica-Krezel
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Axis formation--beta-catenin catches a Wnt

Jason R Jessen et al. Cell. .
Free article

Abstract

In this issue of Cell, the Heasman group implicates Wnt11 as a component of the canonical Wnt signaling pathway that specifies Xenopus laevis axis formation (Tao et al., 2005). This important work not only identifies a long-sought-after dorsalizing factor but also highlights the pivotal role of extracellular cofactors in specifying the activation of either canonical or noncanonical Wnt pathways.

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