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Review
. 2005 Apr;16(2):261-9.
doi: 10.1016/j.semcdb.2004.12.004. Epub 2005 Jan 16.

Programmed cell death in the embryonic vertebrate limb

Vanessa Zuzarte-Luis  1 , Juan M Hurle
Affiliations
Review

Programmed cell death in the embryonic vertebrate limb

Vanessa Zuzarte-Luis et al. Semin Cell Dev Biol. 2005 Apr.

Abstract

The developing limb bud provides one of the best examples in which programmed cell death exerts major morphogenetic functions. In this work, we revise the distribution and the developmental significance of cell death in the embryonic vertebrate limb and its control by the BMP signalling pathway. In addition, paying special attention to the interdigital apoptotic zones, we review current data concerning the intracellular death machinery implicated in mesodermal limb apoptosis.

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