Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2005 Apr 7;11(13):2035-8.
doi: 10.3748/wjg.v11.i13.2035.

Transhepatic fibrinolysis of mesenteric and portal vein thrombosis in a patient with ulcerative colitis: a case report

Alfredo Guglielmi  1 , Francesca Fior, Orsolya Halmos, Gian Franco Veraldi, Lorenzo Rossaro, Andrea Ruzzenente, Claudio Cordiano
Affiliations
Review

Transhepatic fibrinolysis of mesenteric and portal vein thrombosis in a patient with ulcerative colitis: a case report

Alfredo Guglielmi et al. World J Gastroenterol. .

Abstract

Aim: To present a case of acute mesenteric and portal vein thrombosis treated with thrombolytic therapy in a patient with ulcerative colitis in acute phase and to review the literature on thrombolytic therapy of mesenteric-portal system. Treatment of acute portal vein thrombosis has ranged from conservative treatment with thrombolysis and anticoagulation therapy to surgical treatment with thrombectomy and/or intestinal resection.

Methods: We treated our patient with intraportal infusion of plasminogen activator and then heparin through a percutaneous transhepatic catheter.

Results: Thrombus resolved despite premature interruption of the thrombolytic treatment for neurological complications, which subsequently resolved.

Conclusion: Conservative management with plasminogen activator, could be considered as a good treatment for patients with acute porto-mesenteric thrombosis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Partial occlusion of the main portal vein (left) and complete occlusion of prossimal superior mesenteric vein (right) shown on abdominal CT-angiogram.
Figure 2
Figure 2
Complete occlusion of the right branch and partial occlusion of the main portal vein and proximal portion of superior mesenteric vein shown by angiography via transhepatic cathether.
Figure 3
Figure 3
Complete resolution of superior mesenteric and main portal vein thrombosis and partial resolution of thrombi in right portal branch shown by angiography via transhepatic cathether (48 h follow up).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Boughton BJ. Hepatic and portal vein-thrombosis. BMJ. 1991;302:192–193. - PMC - PubMed
    1. Belli L, Romani F, Riolo F, Rondinara G, Aseni P, Di Stefano M, Contorni L, Bini M. Thrombosis of portal vein in absence of hepatic disease. Surg Gynecol Obstet. 1989;169:46–49. - PubMed
    1. Talbot RW, Heppell J, Dozois RR, Beart RW. Vascular complications of inflammatory bowel disease. Mayo Clin Proc. 1986;61:140–145. - PubMed
    1. Yankes JR, Uglietta JP, Grant J, Braun SD. Percutaneous transhepatic recanalization and thrombolysis of the superior mesenteric vein. AJR Am J Roentgenol. 1988;151:289–290. - PubMed
    1. Bilbao JI, Rodriguez-Cabello J, Longo J, Zornoza G, Páramo J, Lecumberri FJ. Portal thrombosis: percutaneous transhepatic treatment with urokinase--a case report. Gastrointest Radiol. 1989;14:326–328. - PubMed

Substances