Review
doi: 10.1016/j.mib.2005.02.005.
Structural and mechanistic diversity of secondary transporters
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- PMID: 15802247
- DOI: 10.1016/j.mib.2005.02.005
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Review
Structural and mechanistic diversity of secondary transporters
Curr Opin Microbiol.
2005 Apr.
Free article
Abstract
Recent reports on the three-dimensional structure of secondary transporters have dramatically increased our knowledge of the translocation mechanism of ions and solutes. The structures of five transporters at atomic resolution have yielded four different folds and as many different translocation mechanisms. The structure of the glutamate transporter homologue GltPh confirmed the role of pore-loop structures as essential parts of the translocation mechanism in one family of secondary transporters. Biochemical evidence for pore-loop structures in several other families suggest that they might be common in secondary transporters, adding to the structural and mechanistic diversity of secondary transporters.
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