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. 2005 Apr;53(4):378-81.
doi: 10.1248/cpb.53.378.

Three new cholinesterase-inhibiting cis-clerodane diterpenoids from Otostegia limbata

Viqar Uddin Ahmad  1 , Afsar Khan, Umar Farooq, Farzana Kousar, Saleha Suleman Khan, Sarfraz Ahmad Nawaz, Muhammad Athar Abbasi, Muhammad Iqbal Choudhary
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Free article

Three new cholinesterase-inhibiting cis-clerodane diterpenoids from Otostegia limbata

Viqar Uddin Ahmad et al. Chem Pharm Bull (Tokyo). 2005 Apr.
Free article

Abstract

Three new tricyclic cis-clerodane type diterpenoids trivially named as limbatolide A (1), limbatolide B (2) and limbatolide C (3) have been isolated from the roots of Otostegia limbata along with two known compounds; oleanic acid and beta-sitosterol. The structure elucidation of the new compounds was based primarily on two-dimensional (2D) NMR techniques. Compounds 1-3 displayed inhibitory potential in a concentration-dependent manner against acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BChE; EC 3.1.1.8) enzymes, respectively.

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