How do thiazide and thiazide-like diuretics lower blood pressure?
- PMID: 15803433
- DOI: 10.3317/jraas.2004.034
How do thiazide and thiazide-like diuretics lower blood pressure?
Abstract
Thiazide diuretics are widely used for the treatment of hypertension, but the mechanism by which these drugs lower blood pressure in the long term remains unknown. This article reviews current knowledge about the hypotensive actions of thiazides and thiazide-like diuretics and discusses possible mechanisms of action.
Similar articles
-
[Diuretics for therapy of patients with hypertension].Nihon Rinsho. 1997 Aug;55(8):2039-44. Nihon Rinsho. 1997. PMID: 9284421 Review. Japanese.
-
Do thiazide diuretics confer specific protection against strokes?Arch Intern Med. 2003 Nov 24;163(21):2557-60. doi: 10.1001/archinte.163.21.2557. Arch Intern Med. 2003. PMID: 14638555 Review.
-
[Profile of the action of diuretics. Piretanide in comparison with thiazides and anti-kaliuretic drugs].Internist (Berl). 1992 Aug;33 Suppl 1:S16-22. Internist (Berl). 1992. PMID: 1428690 Review. German. No abstract available.
-
[Revival of antihypertensive therapy: use of thiazide diuretics].Orv Hetil. 2004 Mar 28;145(13):669-76. Orv Hetil. 2004. PMID: 15125317 Review. Hungarian.
-
[The basic groups of modern diuretic preparations. I. The mechanisms and location of the action of diuretic preparations in the nephron. Carbonic anhydrase inhibitors. Thiazide and thiazide-like diuretics].Ter Arkh. 1992;64(4):107-12. Ter Arkh. 1992. PMID: 1440294 Russian. No abstract available.
Cited by
-
Hypertension in athletes.J Clin Hypertens (Greenwich). 2009 Apr;11(4):226-33. doi: 10.1111/j.1751-7176.2009.00100.x. J Clin Hypertens (Greenwich). 2009. PMID: 19614807 Free PMC article. Review.
-
Meta-analysis of dose-response relationships for hydrochlorothiazide, chlorthalidone, and bendroflumethiazide on blood pressure, serum potassium, and urate.Hypertension. 2012 Jun;59(6):1104-9. doi: 10.1161/HYPERTENSIONAHA.111.190637. Epub 2012 Apr 30. Hypertension. 2012. PMID: 22547443 Free PMC article.
-
Genome Wide Association Study Identifies the HMGCS2 Locus to be Associated With Chlorthalidone Induced Glucose Increase in Hypertensive Patients.J Am Heart Assoc. 2018 Mar 9;7(6):e007339. doi: 10.1161/JAHA.117.007339. J Am Heart Assoc. 2018. PMID: 29523524 Free PMC article.
-
Thiazide and thiazide-like diuretics: an opportunity to reduce blood pressure in patients with advanced kidney disease.Curr Hypertens Rep. 2012 Oct;14(5):416-20. doi: 10.1007/s11906-012-0293-4. Curr Hypertens Rep. 2012. PMID: 22886538 Review.
-
Mechanisms and pharmacogenetic signals underlying thiazide diuretics blood pressure response.Curr Opin Pharmacol. 2016 Apr;27:31-7. doi: 10.1016/j.coph.2016.01.005. Epub 2016 Feb 10. Curr Opin Pharmacol. 2016. PMID: 26874237 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical