Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2005 Feb;11(1):76-81.
doi: 10.1080/13550280590900436.

The application of reverse genetics technology in the study of rabies virus (RV) pathogenesis and for the development of novel RV vaccines

Matthias J Schnell  1 , Gene S Tan, Bernhard Dietzschold
Affiliations
Review

The application of reverse genetics technology in the study of rabies virus (RV) pathogenesis and for the development of novel RV vaccines

Matthias J Schnell et al. J Neurovirol. 2005 Feb.

Abstract

Rabies is a central nervous system (CNS) disease that is almost invariably fatal. Neurotropism, neuroinvasiveness, and transsynaptic spread are the main features that determine the pathogenesis of rabies. Recent advances in rabies virus (RV) research, which made direct genetic manipulations of the RV genome possible, greatly improved the understanding of the role of different viral and host cell factors in the pathogenesis of rabies. Here the authors discuss molecular mechanisms associated with rabies RV infection and its spread to the CNS.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Virol. 1999 Jan;73(1):242-50 - PubMed
    1. J Virol. 2002 Jan;76(1):19-31 - PubMed
    1. Hum Mol Genet. 2001 Sep 15;10(19):2109-21 - PubMed
    1. J Virol. 2000 Nov;74(21):10217-22 - PubMed
    1. J Virol. 1985 Oct;56(1):12-8 - PubMed

Publication types

Substances

LinkOut - more resources