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. 2005 Apr;132(4):598-601.
doi: 10.1016/j.otohns.2004.09.060.

Use of mitomycin C for treatment of keloid: a preliminary report

Yoav P Talmi  1 , Arie Orenstein, Michael Wolf, Jona Kronenberg
Affiliations

Use of mitomycin C for treatment of keloid: a preliminary report

Yoav P Talmi et al. Otolaryngol Head Neck Surg. 2005 Apr.

Abstract

Objectives: Mitomycin C (MC) is an anti-neoplastic agent with an anti-proliferative effect on fibroblasts. We set out to evaluate the effect of MC application following keloid excision.

Study design and setting: Patients with keloid in a tertiary referral center were enrolled in a prospective study. The scar was excised and prior to skin closure, a pledget with 1 cc of MC 0.4 mg/mL was applied for 5 minutes. Patient satisfaction and keloid thickness were assessed.

Results: All patients were satisfied with the results, although complete disappearance of the keloid was evident only in two. Keloid thickness was measured and ranged from 5 to 26 mm. Following surgery and treatment at 2 months thickness ranged from 0 to 8 mm.

Conclusions: MC application following scar resection appears to be effective in treatment of keloid.

Significance: As no specific effective treatment for keloid is currently available, utilization of this readily available therapeutic agent may improve treatment outcome.

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