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Review
. 2005 Apr 4;201(7):1025-9.
doi: 10.1084/jem.20050499.

Understanding how combinations of HLA and KIR genes influence disease

Sumati Rajagopalan  1 , Eric O Long
Affiliations
Review

Understanding how combinations of HLA and KIR genes influence disease

Sumati Rajagopalan et al. J Exp Med. .

Abstract

Combinations of HLA and killer cell immunoglobulin-like receptor (KIR) genes have been associated with diseases as diverse as autoimmunity, viral infections, reproductive failure, and now cancer. Much as early observations of disease associations with HLA polymorphism preceded a detailed knowledge of HLA recognition by T cell receptors, the recently reported disease associations with HLA-KIR gene combinations beg for a better understanding of the underlying mechanisms.

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References

    1. Carrington, M., S. Wang, M.P. Martin, X. Gao, M. Schiffman, J. Cheng, R. Herrero, A.C. Rodriguez, R. Kurman, R. Mortel, et al. 2005. Hierarchy of resistance to cervical neoplasia mediated by combinations of KIR and HLA loci. J. Exp. Med. 201:1069–1075. - PMC - PubMed
    1. Martin, M.P., X.J. Gao, J.H. Lee, G.W. Nelson, R. Detels, J.J. Goedert, S. Buchbinder, K. Hoots, D. Vlahov, J. Trowsdale, et al. 2002. Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat. Genet. 31:429–434. - PubMed
    1. van der Slik, A.R., B.P. Koeleman, W. Verduijn, G.J. Bruining, B.O. Roep, and M.J. Giphart. 2003. KIR in type 1 diabetes: disparate distribution of activating and inhibitory natural killer cell receptors in patients versus HLA-matched control subjects. Diabetes. 52:2639–2642. - PubMed
    1. Khakoo, S.I., C.L. Thio, M.P. Martin, C.R. Brooks, X. Gao, J. Astemborski, J. Cheng, J.J. Goedert, D. Vlahov, M. Hilgartner, et al. 2004. HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection. Science. 305:872–874. - PubMed
    1. Nelson, G.W., M.P. Martin, D. Gladman, J. Wade, J. Trowsdale, and M. Carrington. 2004. Cutting edge: heterozygote advantage in autoimmune disease: hierarchy of protection/susceptibility conferred by HLA and killer Ig-like receptor combinations in psoriatic arthritis. J. Immunol. 173:4273–4276. - PubMed