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Comment
. 2005 Apr 12;102(15):5308-9.
doi: 10.1073/pnas.0501853102. Epub 2005 Apr 5.

Histone modifications: combinatorial complexity or cumulative simplicity?

Steven Henikoff  1
Affiliations
Comment

Histone modifications: combinatorial complexity or cumulative simplicity?

Steven Henikoff. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
Testing the histone code hypothesis. Dion et al. (4) constructed all combinations in which one, two, or three of the four histone lysine residues were changed to arginine (black rectangles) and measured expression levels (vertical bars). For gene 1, monotonic decreases in expression are seen with increases in the number of K-to-R changes regardless of the particular residue changed. For gene 2, monotonic increases in expression are seen. For gene 3, there are significant incremental expression changes attributable to K16 (magenta bars), calculated by comparing the K16 value to the average of K5, -8, and -12 values (green bars). This finding indicates that changing K16 to R has an effect on gene 3 that is discordant with changes of K5, -8, and -12 to R.
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