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Comment
. 2005 Apr;3(4):e131.
doi: 10.1371/journal.pbio.0030131.

Alchemy and the new age of cardiac muscle cell biology

Affiliations
Comment

Alchemy and the new age of cardiac muscle cell biology

Kenneth R Chien. PLoS Biol. 2005 Apr.

Abstract

Several studies have claimed to identify cardiac stem cells. But what criteria do such cells have to fulfil before we can be confident about their true potential?

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Figures

Figure 1
Figure 1. Islet-1-Positive Cardioblast in the Right Ventricular Chamber of the Neonatal Rat Heart
Islet-1 nuclear staining depicted in green, nuclear staining in blue, myocyte marker staining in red. The left panel shows triple staining; the right panel shows single staining for Islet-1 expression.

Comment on

References

    1. Winitsky SO, Gopal TV, Hassanzadeh S, Takahashi H, Gryder D, et al. Adult murine skeletal muscle contains cells that can differentiate into beating cardiomyocytes in vitro. PLoS Biol. 2005;3:e87. - PMC - PubMed
    1. Sherwood RI, Christensen JL, Conboy IM, Conboy MJ, Rando TA, et al. Isolation of adult mouse myogenic progenitors: Functional heterogeneity of cells within and engrafting skeletal muscle. Cell. 2004;119:543–554. - PubMed
    1. Laugwitz KL, Moretti A, Lam J, Gruber P, Chen Y, et al. Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature. 2005;433:647–653. - PMC - PubMed
    1. Chien KR. Stem cells: Lost in translation. Nature. 2004;428:607–608. - PubMed
    1. Lapidos KA, Chen YE, Earley JU, Heydemann A, Huber JM, et al. Transplanted hematopoietic stem cells demonstrate impaired sarcoglycan expression after engraftment into cardiac and skeletal muscle. J Clin Invest. 2004;114:1577–1585. - PMC - PubMed