Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 May;111(5):323-8.
doi: 10.1111/j.1600-0404.2005.00397.x.

Low blood pressure is a better predictor of cognitive deficits than the apolipoprotein e4 allele in the oldest old

K Hestad  1 , B Kveberg, K Engedal
Affiliations

Low blood pressure is a better predictor of cognitive deficits than the apolipoprotein e4 allele in the oldest old

K Hestad et al. Acta Neurol Scand. 2005 May.

Abstract

Objective: To study the correlates of cognitive deficits in persons 80 years and older.

Materials and methods: Data from 271 individuals between 80 and 102 years of age, drawn from a central registrar (response rate 50%) were analyzed regarding e apolipoprotein E (Apo-E) polymorphism, blood pressure (BP), homocysteine, sex, age and education as predictors for low score on Mini Mental Status Examination (MMSE).

Results: Low systolic and diastolic BP were highly associated with low score on the MMSE, followed by age and Apo-E e4. No relationship was found between Apo-E allele groups and BP. Homocysteine, sex, and education were only of marginal importance.

Conclusions: Hypotension is an important factor for performance on the MMSE. To some extent, this was also true for having the Apo-E e4 allele. A combined effect on cognition for these two factors was not found.

PubMed Disclaimer

Publication types

LinkOut - more resources