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Clinical Trial
. 2005 Apr 15;95(8):973-5.
doi: 10.1016/j.amjcard.2004.12.038.

Compliance as a critical consideration in patients who appear to be resistant to aspirin after healing of myocardial infarction

Kenneth A Schwartz  1 , Dianne E Schwartz, Khalid Ghosheh, Mathew J Reeves, Kimberly Barber, Anthony DeFranco
Affiliations
Clinical Trial

Compliance as a critical consideration in patients who appear to be resistant to aspirin after healing of myocardial infarction

Kenneth A Schwartz et al. Am J Cardiol. .

Abstract

The hypothesis that aspirin resistance is often due to noncompliance was investigated. One hundred ninety patients with a history of myocardial infarction were evaluated using arachidonic acid-stimulated light aggregometry at 3 different time points: while receiving their usual daily aspirin, after not receiving aspirin for 7 days, and 2 hours after the observed ingestion of aspirin 325 mg. At the first time point, 17 patients (9%) failed to show aspirin inhibition of platelet aggregation, but 2 hours after observed aspirin ingestion, aspirin inhibition was observed in all but 1 patient.

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