Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2005 Apr 8;121(1):2-4.
doi: 10.1016/j.cell.2005.03.017.

Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling

M Datto  1 , X-F Wang
Affiliations
Free article
Comment

Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling

M Datto et al. Cell. .
Free article

Abstract

Effects of the cytokine TGF-beta can be dampened by E3 ubiquitin ligases that target specific Smads, the TGF-beta signal transducers, for proteolytic destruction. Two papers in this issue of Cell highlight the importance of this mechanism in regulating the in vivo effects of TGF-beta. The first paper identifies and characterizes a novel Smad4 ubiquitin ligase, and the second paper redefines the role of a previously identified Smad1 ubiquitin ligase, Smurf-1 (Dupont et al., 2005; Yamashita et al., 2005).

PubMed Disclaimer

Comment on

MeSH terms

LinkOut - more resources