Comment
doi: 10.1016/j.cell.2005.03.018.
Axon guidance: opposing EPHects in the growth cone
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- PMID: 15820672
- DOI: 10.1016/j.cell.2005.03.018
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Comment
Axon guidance: opposing EPHects in the growth cone
Cell.
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Abstract
Cells communicate with other cells via (trans) interaction between membrane-linked ephrins and Eph receptors. In this issue of Cell, Pfaff and colleagues (Marquardt et al., 2005) demonstrate that coexpressed ephrin-As and Ephs do not interact in cis but rather segregate into separate membrane domains, from which they signal opposing effects during motor axon guidance.
Comment on
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Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domains.Cell. 2005 Apr 8;121(1):127-39. doi: 10.1016/j.cell.2005.01.020. Cell. 2005. PMID: 15820684
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