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. 2005 Apr;83(4):1060-3.
doi: 10.1016/j.fertnstert.2004.12.002.

Evidence for a histaminergic system in the human testis

Martin Albrecht  1 , Monica B Frungieri, Silvia Gonzalez-Calvar, Viktor Meineke, Frank M Köhn, Artur Mayerhofer
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Free article

Evidence for a histaminergic system in the human testis

Martin Albrecht et al. Fertil Steril. 2005 Apr.
Free article

Abstract

The complete lack of information about mast cells as a source of histamine and potential target cells for histamine in human testes prompted us to investigate these issues in testes of fertile and infertile patients using a combination of laser microdissection, reverse transcription-polymerase chain reaction (RT-PCR), and immunohistochemistry. We show for the first time the expression of the rate-limiting enzyme in histamine synthesis-histidine decarboxylase-by human testicular mast cells and the expression of the histamine (H) receptors 1 (H1) and 2 (H2) by germinal, interstitial, and peritubular cells in the testes of fertile and infertile patients.

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