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. 2005 Apr 12;64(7):1294-7.
doi: 10.1212/01.WNL.0000156914.16988.56.

CSF Abeta42 and tau or phosphorylated tau and prediction of progressive mild cognitive impairment

Sanna-Kaisa Herukka  1 , Merja Hallikainen, Hilkka Soininen, Tuula Pirttilä
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CSF Abeta42 and tau or phosphorylated tau and prediction of progressive mild cognitive impairment

Sanna-Kaisa Herukka et al. Neurology. .

Abstract

Baseline CSF amyloid beta-peptide-42 (Abeta42), tau, and phosphorylated tau (P-tau) levels from 46 control subjects and 78 patients with mild cognitive impairment (MCI) were measured. Twenty-three patients with MCI developed dementia during the study. Abnormal biomarkers were found early in the course of Alzheimer disease (AD). The most predictive assay for AD among the patients with MCI was the combination of Abeta42 and P-tau.

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